The Great DNA Data Deficit: Are Genes for Disease a Mirage?

Jonathan Latham and Allison Wilson

Just before his appointment as head of the US National Institutes of Health (NIH), Francis Collins, the most prominent medical geneticist of our time, had his own genome scanned for disease susceptibility genes. He had decided, so he said, that the technology of personalised genomics was finally mature enough to yield meaningful results. Indeed, the outcome of his scan inspired The Language of Life, his recent book which urges every individual to do the same and secure their place on the personalised genomics bandwagon.

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Biology as Ideology: The Doctrine of DNA

Author: by Richard Lewontin

ISBN: 0140232192 Publisher: Penguin books (1991)

Biologists know that complex traits are typically associated with genetic variation between individuals. Nevertheless, if we hear on the news that obesity, antisocial behaviour or some other disorder has a strong genetic component, we are likely to attach special significance to this ‘fact’. We may be less likely to attribute social factors as a cause and we may be more likely to accept a technological or pharmaceutical solution as a remedy. The disorder may also acquire a credibility and a sense of inevitability that it previously lacked. The reasoning that leads to these conclusions has a certain logic, after all we investigate causes primarily so that we can find remedies, but nevertheless we need to be careful that our thinking is well-founded.

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What is Nature Biotechnology good for?

Jonathan Latham and Allison Wilson

The case of Irina Ermakova

Quite likely it surprised many regular readers of Nature Biotechnology that for the September (2007) issue their journal had invented a new article format specifically in order to describe, and then extensively criticise, the work of a researcher that most of them had never heard of before (1). That surprise will only increase if they read the translation, featured on our website, of a Nov 1st article (The excommunication of a heretic) in the Swiss Newspaper WOZ. Readers who thought this new format was simply a curious, if rather aggressive, literary innovation, can now see that this was a story with a disturbing history. Even more interesting however than the ethical shenanigans behind the publication of the interview with Dr Ermakova, is a point not raised by the Swiss newspaper article.

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